Diabetes and obesity represent probably the best known disease pair with such significant comorbidity. In the disease gene network dgn nodes represent disease genes. Interactome networks and human disease sciencedirect. The expanded human disease network combining proteinprotein interaction information article pdf available in european journal of human genetics 197. Jonesc,d departments of abiology, bcomputer sciences, and canthropology, and dwoods institute for the environment, stanford university, stanford, ca 943055020 edited by adrian raftery, university of washington. In the human disease network hdn nodes represent disorders, and two disorders are connected to each other if they share at least one gene in which mutations are associated with both disorders figs. Additional types of connectivity between large numbers of human diseases can be found in comorbidity networks where diseases are linked to each other when individuals who were diagnosed for one particular disease are more likely to have also been diagnosed for the other rzhetsky et al. We consider shared ppis of 1st order directly connected proteins. Pdf the expanded human disease network combining protein.
Because blood mediates coordination between nonadjacenttissues, it is of the highest interestto understandifandhowthisregulationoccursviaserum proteins and their networks. Emerging and reemerging viral infectious diseases joseph becker, md michele barry, md facp yale university school of medicine january, 2009 prepared as part of an education project of the. Chikungunya disease in nonhuman primates involves long. Human symptomsdisease network xuezhong zhou1,2,3, jo. Pdf this chapter on the articular, muscle, adipose tissue, and bone diseases of. A highresolution human contact network for infectious disease transmission marcel salathea,1,2, maria kazandjievab, jung woo leeb, philip levisb, marcus w. A link is placed between a disorder and a disease gene if mutations in that gene lead to the speci. Centerasmallsubsetofomimbaseddisorderdiseasegeneassociations18,wherecirclesandrectangles correspond to disorders and disease genes, respectively. Disease gene network dgn disease phenome disease genome diseasome fig. Pdf arthritis, muscle, adipose tissue, and bone diseases of. Article pdf available in nature 5147520 august 2014 with 765 reads.
Practical strategies for improving the use of animal models for studying human disease include designing human clinical trials that replicate the conditions that were tested for in. Reversion of advanced ebola virus disease in nonhuman primates with zmapp. Pdf reversion of advanced ebola virus disease in nonhuman. Heart valve disease resources american heart association. Appropriateness of animal models for studying human disease.
A leaflet about euprimnet is available for download here pdf, 3. Humans and nonhuman primates, both placed to the order primates, are. A network of disorders and disease genes linked by known disorder gene associations offers a platform to explore in a single graph theoretic. A highresolution human contact network for infectious.
The human disease network article pdf available in proceedings of the national academy of sciences 10421. Coregulatory networks of human serum proteins link. Linking all genetic disorders with all disease genes. The most common cause of dementia is alzheimers disease ad, accounting for nearly 60 to. Primaten zijn echter net als andere dieren ook gevoelig voor. A network of disorders and disease genes linked by known disordergene associations offers a platform to explore in a single graphtheoretic framework all known phenotype and disease gene associations, indicating the common genetic origin of many diseases. Use of nonhuman primates in obstructive lung disease research is. Ebola virus ebov causes a highly virulent systemic disease, ebola. Characterization of the plasma proteome of nonhuman primates. A network of disorders and disease genes linked by known disordergene associations offers a platform to explore in a single graphtheoretic.
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